Common drug linked to longevity in mice

Metformin, used worldwide to treat Type 2 diabetes (in which the body does not appropriately respond to insulin in the bloodstream, leading to excessive amounts of insulin in the blood), may be one of the most prescribed drugs for this condition. This drug doesn't just treat the insulin; unlike most drugs, this one also helps prevent many of the cardiovascular problems associated with the hormonal imbalances of diabetes. It is also commonly used to treat polycystic ovarian disorder and metabolic syndrome, two disorders still not completely understood. A new study released in Nature Communication this month revealed that when fed in very low doses to middle aged mice, metformin actually did more. This drug seemed to mimic the effects of a low-calorie diet; namely, it increased the lifespan of the mice in the experimental group. However, in higher doses, metformin did enough kidney damage to significantly shorten lifespans - in fact, it shortened lives by more than the lower dose lengthened them.

It's still an interesting result, and it's worth remember that studying animal models allow us to discover which paths are worth pursuing in human models, with all the risks that entails, in a safer, faster, more humane manner.

Watch for more on this to come...

My husband shared this TEDMed talk with me tonight, and I wanted to share it with you, along with Dr. Attia's blog. It takes courage for doctors to deviate from traditional wisdom or the accepted dogma and consider new approaches to existing problems. However, I've found that, in my own personal experience, the evidence he seems to be describing is accurate: I've found that eating more whole grains and fewer refined carbohydrates is far better for me and my diet than any low-fat approach ever attempted (low-fat seems to always actually result in higher cholesterol for me, meaning that my body compensates for the lower dietary intake by raising the production, indicating an internal imbalance that diet alone can't correct). I'll be following Dr. Attia, and I hope to have more information for you in the months and years to come.